中 文 | English







沈力

研究助理

: +86-15250412231
: lishen0709@gmail.com
: www.leeshen.net
: 成都









2012 - 2016 东华大学 生物工程
  • 大学加权均分:77/100。
  • 大学主修课程:生物化学,分子生物学,细胞生物学,JAVA编程,生物信息学。
  • 自学数据结构与算法,Python编程,R编程与生物统计。

  • 2014 - 2016 苏州大学 科研助理(兼职)
  • 与苏州⼤学附属第⼀医院和苏州市⼉童医院合作,运⽤⽣物信息学⽅法对microarray、RNA-seq数据进挖掘,构建疾病特异的microRNA⽣物标志物预测络模型。
  • 发表SCI论文5篇,其中1篇1作(Scientific Reports, IF: 3.998),1篇共一作(Advances in Protein Chemistry and Structural Biology, IF: 3.01),3篇共同作者。

  • 2015.7 - 2015.9 University of California - San Diego iDASH暑期实习生
  • 运⽤R Shiny和Python,协助构建⽤于病⼈EHR数据安全共享的云平台。
  • 合作发表论⽂⼀篇,获得计算机A级会议AMIA“2016最佳学⽣论⽂奖”。

  • 2016 - 2017 苏州大学 科研助理
  • 协助实验室PI撰写书籍章节和杂志review。
  • 参与实验室研究生课题研究,辅助分析microarray,RNA-seq数据。
  • 指导本科⽣相关⽣物信息学⼯具使⽤(如IPA、KEGG、Cytoscape等等),并参与本实验室研究⽣的相关课题研究。
  • 负责实验室⽇常管理与假期活动策划。
  • 发表SCI论文7篇,一作1篇(Advances in Experimental Medicine and Biology, IF: 2.45),共同作者6篇。

  • 2017 - 2018 Yale University Postgraduate Associate
  • 负责实验室测序数据分析处理,包括RNA-seq、single cell RNA-seq等等。
  • 主要参与实验室⼀项课题,开发基于CRISPR-CPF1的体内⼤规模基因双敲除筛选系统。
  • 辅助实验室博⼠⽣和博⼠后做基本⽣物学实验。
  • 以共同作者⾝份发表Nature Methods,Nature Immunology,Cell Systems各1篇。

  • 2018 - 2019 Rutgers - New Jersey Medical School Research Assistant
  • 负责实验室测序数据分析,基于RNA-seq数据结合已发表的数据库构建⽣物过程特异的microRNA-mRNA调控⽹络,寻找关键microRNA。
  • 负责数据库和云平台策划与搭建。

  • 2020 - 现在 四川大学华西医院 研究助理
  • 在研项目:细胞因子风暴数据库搭建与风险预测。
  • 与医院临床科室合作,负责ATAC-seq、RNA-seq和Single Cell测序分析。
  • 目前已发表1篇SCI论文,一作1篇(Pharmacological Research, IF: 5.89)。

  • 2013 上海科技馆“志愿⼯作积极分⼦”称号
    2016 American Medical Informatics Association 最佳学⽣论⽂奖 - 转化⽣物信息学领域

    生物学实验 分⼦克隆,细胞培养,⼩⿏解剖,CRISPR基因编辑。
    生物信息学 Bulk RNA-seq分析(差异表达,SNP分析),Single-cell RNA-seq分析(10x Genomics Cell Ranger, Seurat等),⽹络分析(Cytoscape,WGCNA),数据库搭建(MySQL),⽂献/⽹络信息挖掘(CiteSpace,Scrapy,BeautifulSoup等等),数据可视化(ggplot,pandas等等),⽹络开发(Vue,Django)。
    计算机语言 R,Python,HTML,MySQL,Linux Shell,JavaScript。

    期刊论文
    N/A CSSKD: A knowledge base for cytokine storm syndrome
    (first author)
    In preparation
    N/A Altered nitric oxide induced by gut microbiota reveals the connection between central precocious puberty and obesity
    (Co-first author)
    Submitted to Clinical & Translational Medicine
    N/A MiR-378a-3p as a biomarker for hepatocellular carcinoma diagnosis and prognosis: computational screening with experimental validation Under review by Clinical & Translational Medicine
    2020 Data-driven microbiota biomarker discovery for personalized drug therapy of cardiovascular disease
    (first author)
    Pharmacological Research
    2019 Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity Nature Immunology
    2019 In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens Nature Methods
    2019 Computer-aided biomarker discovery for precision medicine: data resources, models and applications Briefings In Bioinformatics
    2019 Convergent identification and interrogation of tumor-intrinsic factors that modulate cancer immunity in vivo Cell Systems
    2018 Biomarker microRNAs for prostate cancer metastasis: screened with a network vulnerability analysis model Journal of Translational Medicine
    2018 MiRNA-BD: an evidence-based bioinformatics model and software tool for microRNA biomarker discovery RNA Biology
    2018 NDDVD: an integrated and manually curated Neurodegenerative Diseases Variation Database Database
    2017 Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network Oncotarget
    2016 Knowledge-guided bioinformatics model for identifying autism spectrum disorder diagnostic MicroRNA biomarkers
    (first author)
    Scientific Reports
    2016 Biomarker MicroRNAs for diagnosis, prognosis and treatment of hepatocellular carcinoma: a functional survey and comparison Scientific Reports
    书籍章节
    2017 Physiological informatics: collection and analyses of data from wearable sensors and smartphone for healthcare Advances in Experimental Medicine and Biology
    2017 Systems health: a transition from disease management toward health promotion
    (first author)
    Advances in Experimental Medicine and Biology
    2015 Understanding amino acid mutations in hepatitis B virus proteins for rational design of vaccines and drugs
    (Co-first author)
    Advances in Protein Chemistry and Structural Biology
    会议论文
    2017 PALME: PAtients Like My gEnome AMIA Summits on Translational Science Proceedings 2016